MM-102 TFA ( HMTase Inhibitor IX TFA )

产品货号. M22741 CAS No. 1883545-52-5

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

MM-102 TFA
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

MM-102 TFA 是一种有效的 WDR5/MLL 相互作用抑制剂，IC50 = 2.4 nM。 MM-102 化合物可防止混合谱系白血病 1 (MLL1) 和 WD Trp-Asp 重复结构域 5 (WDR5) 之间的相互作用，并抑制 MLL1 H3K4 组蛋白甲基转移酶 (HMT) 活性。
产品描述

MM-102 TFA is a potent WDR5/MLL interaction inhibitor, achieves IC50 = 2.4 nM.?MM-102 compound prevents the interaction between mixed lineage leukemia 1 (MLL1) and WD Trp-Asp repeat domain 5 (WDR5) and results in the inhibition of MLL1 H3K4 histone methyltransferase (HMT) activity.?Down-Regulation of H3K4me3 by MM-102 Facilitates Epigenetic Reprogramming of Porcine Somatic Cell Nuclear Transfer EmbryMM-102, in bone marrow cells transduced with MLL1-AF9 fusion construct shows that the compound effectively decreases the expression of HoxA9 and Meis-1, two critical MLL1 target genes in MLL1 fusion protein mediated leukemogenesis.?MM-102 also specifically inhibits cell growth and induces apoptosis in leukemia cells harboring MLL1 fusion proteins.?
体外实验

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体内实验

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同义词

HMTase Inhibitor IX TFA
通路

Others
靶点

Other Targets
受体

MLL1
研究领域

——
适应症

——

CAS Number

1883545-52-5
分子量

783.83
分子式

C37H50F5N7O6
纯度

>98% (HPLC)
溶解度

DMSO:99 mg/mL(126.3 mM)
SMILES

OC(=O)C(F)(F)F.CCC(CC)(NC(=O)C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NC1(CCCC1)C(=O)NC(c1ccc(F)cc1)c1ccc(F)cc1
化学全称

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1. Karatas H, et al. J Am Chem Soc. 2013, 135(2), 669-682.

计算器

产品手册

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